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Adenosine deaminase-resistant analogue with antileukemic properties, probably effective via its corresponding triphosphate. Detailed technical information available. References: Wang et al., J. Biol. Chem., 268, 22847 - 22852 (1993).; Beutler, Semin. Hematol., 31, 40 - 45 (1994). This compound is also part of the Ko-Libri compound library (K 001)
Cat. No.
C 028
CAS number
[4291-63-8]
Purity
> 97% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₁₀H₁₂ClN₅O₃
Molecular weight [g/mol]
285.7
Absorption max [nm]
263
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
14000
1. Leoni L. M., Chao Q., Cottam H. B., Genini D., Rosenbach M., Carrera C. J., Budihardjo I., Wang X.Carson D. A., Proc. Natl. Acad. Sci. USA, 95, 9567 - 9571 (1998), "Induction of an Apoptotic Program in Cell-free Extracts by 2-Chloro-2'-deoxyadenosine 5'-triphosphate and Cytochrome C"
2. Coomber D. W. J., O'Sullivan W. J.Gero A. M., Int. J. Parasitol., 24, 357 - 365 (1994), "Adenosine Analogues as Antimetabolites against Plasmodium Falciparum Malaria"
3. Beutler E., Semin. Hematol., 31, 40 - 45 (1994), "New Chemotherapeutic Agent: 2-Chlorodeoxyadenosine"
4. Wang L., Karlsson A., Arner E. S. J.Eriksson S., J. Biol. Chem., 268, 22847 - 22852 (1993), "Substrate Specificity of Mitochondrial 2'-Deoxyguanosine Kinase. Efficient Phosphorylation of 2-Chlorodeoxyadenosine"