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6-Phe-ADP

N6- Phenyladenosine- 5'- O- diphosphate ( 6-Phe-ADP ), sodium salt

Cat. No.: P 014
    
CAS No.: [105701-92-6]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: P 014-05
Unit: 5 µmol / ~2.5 mg
$261.00

For other salt forms please inquire. Precursor for the preparation of the corresponding radio-labelled triphosphate to be used in the chemical genetics approach (compare: Habelhah et al., J. Biol. Chem., 276, 18090 - 18095 (2001)). The corresponding cold triphosphate is offered as well (Cat. No. P 015). Detailed technical information available. References: Shah et al., Proc. Natl. Acad. Sci. USA, 94, 3565 - 3570 (1997); Gillespie et al., J. Biol. Chem., 274, 31373 - 31381 (1999).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. P 014
CAS number [105701-92-6]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₆H₁₉N₅O₁₀P₂ (free acid)
Molecular weight [g/mol] 503,3 (free acid)
Absorption max [nm] 288
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 20900
  • 1. Habelhah H., Shah K., Huang L., Burlingame A. L., Shokat K. M.Ronai Z., J. Biol. Chem., 276, 18090 - 18095 (2001), "Identification of New JNK Substrate Using ATP Pocket Mutant JNK and a Corresponding ATP Analogue"
  • 2. Gillespie P. G., Gillespie S. K. H., Mercer J. A., Shah K.Shokat K. M., J. Biol. Chem., 274, 31373 - 31381 (1999), "Engineering of the Myosin-Iß Nucleotide-binding Pocket to Create Selective Sensitivity to N6-modified ADP Analogs"
  • 3. Shah K., Liu Y., Deirmengian C.Shokat K. M., Proc. Natl. Acad. Sci. USA, 94, 3565 - 3570 (1997), "Engineering Unnatural Nucleotide Specificity for Rous Sarcoma Virus Tyrosine Kinase to Uniquely Label its Direct Substrates"
  • 4. Moffat L. D., Brown S. B. A., Grassie M. E., Ulke-Lemée A., Williamson L. M., Walsh M. P.MacDonald J. A., J.Biol.Chem., 286, 36978 - 36991 (0), "Chemical Genetics of Zipper-interacting Protein Kinase Reveal Myosin Light Chain as a Bona Fide Substrate in Permeabilized Arterial Smooth Muscle"