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3'-O-Bn-GTP

3'- O- Benzylguanosine- 5'- O- triphosphate ( 3'-O-Bn-GTP ), sodium salt

Ribose-modified GTP analogue
Cat. No.: B 193
    
CAS No.: [1610778-75-0]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: B 193-01
Unit: 1 µmol / ~0.6 mg
$145.00

For other salt forms or a guaranteed higher purity please inquire. 3'-O-Bn-GTP is an analogue of GTP where the ribose 3'-hydroxy group has been modified by an ether bond to a benzyl group. Significantly improved stability against esterases compared to other 2'/3'-esters of the ribose like MANT-GTP (Cat. M 032). Potential inhibitor of various adenylyl cyclase isoforms and soluble guanylyl cyclase (sGC). References for related GTP analogs and nucleoside triphosphate analogs: Dove et al., Mol. Pharmacol.85, 598 - 607 (2014), Pinto et al., Biochem. Phamacol., 82, 358 - 370 (2011), Geduhn et al., J. Pharmacol. Exp. Ther., 336, 104 - 115 (2011), Gille et al., J. Biol. Chem., 279, 19955 - 19969 (2004)

 

Vial containing 100 µl of 10 mM aqueous solution of pH 7.6.

Cat. No. B 193
CAS number [1610778-75-0]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₇H₂₂N₅O₁₄P₃ (free acid)
Molecular weight [g/mol] 613.3 (free acid)
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 13500
UV pH value 7
Solvent for UV data Water