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2-MeS-5'-AMP / 2-MeSAMP

2- Methylthioadenosine- 5'- O- monophosphate ( 2-MeS-5'-AMP / 2-MeSAMP ), sodium salt

Cat. No.: M 031
    
CAS No.: [22140-20-1]
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Product Name Price (net) Qty
Cat. No.: M 031-10
Unit: 10 µmol / ~3.9 mg
$329.00
For other salt forms please inquire.
Potent adenylate cyclase-coupled platelet ADP P2Y purinoceptor antagonist. Detailed technical information and reference list available. References: Brammer & Maguire, Brit. J. Pharmacol., 82, 61 - 72 (1984); Swennen et al., Biochem. Biophys. Res. Commun., 348, 1194 - 1199 (2006).
Cat. No. M 031
CAS number [22140-20-1]
Purity > 97% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₁H₁₆N₅O₇PS (free acid)
Molecular weight [g/mol] 393.3 (free acid)
Absorption max [nm] 277
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14700
UV pH value 11
  • 1. Herfindal L., Nygaard G., Kopperud R., Krakstad C., Doeskeland S. O.Selheim F., Biochem. Biophys. Res. Commun., 437, 603 - 608 (2013), "Off-Target Effect of the Epac Agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 Receptors in Blood Platelets"
  • 2. Swennen E. L., Bast A.Dagnelie P. C., Biochem. Biophys. Res. Commun., 348, 1194 - 1199 (2006), "Purinergic Receptors Involved in the Immunomodulatory Effects of ATP in Human Blood"
  • 3. Kubista H., Lechner S. G., Wolf A. M.Boehm S., Brit. J. Pharmacol., 138, 343 - 350 (2003), "Attenuation of the P2Y Receptor-mediated Control of Neuronal Ca2+ Channels in PC112 Cells by Antithrombotic Drugs"
  • 4. Jantzen H.-M., Gousset L., Bhaskar V., Vincent D., Tai A., Reynolds E. E.Conley P. B., Thromb. Haemost., 81, 111 - 117 (1999), "Evidence for Two Distinct G-Protein-coupled ADP Receptors Mediating Platelets Activation"
  • 5. Brammer J. P.Maguire M. H., Br. J. Pharmacol., 82, 61 - 72 (1984), "Arachidonate Metabolism, 5-Hydroxytryptamine Release and Aggregation in Human Platelets Activated by Palmitaldehyde Acetal Phosphatidic acid"
  • 6. Cusack N. J.Hourani S. M. O., Br. J. Pharmacol., 75, 397 - 400 (1982), "Specific but Noncompetitive Inhibition by 2-Alkylthio Analogues of Adenosine 5'-monophosphate and Adenosine 5'-triphosphate of Human Platelet Aggregation Induced by Adenosine 5'-diphosphate"