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Rp-2'-AEC-cAMPS-Agarose

2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose gel ( Rp-2'-AEC-cAMPS-Agarose )
Cat. No.: A 126
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 126-06
Unit: 0.6 ml
$210.00
Cat. No.: A 126-25
Unit: 2.5 ml
$657.00
Cat. No.: A 126-60
Unit: 6 ml
$1,323.00

The protein kinase A inhibitor Rp-cAMPS (Cat. No. A 002) immobilized on agarose by an aminoethylcarbamoyl spacer attached to the ribose 2'-position of the ligand. Free Rp-cAMPS is not metabolized by mammalian phosphodiesterases and thus represents an extraordinary stable ligand. In addition, its reduced binding affinity towards protein kinase A compared to cAMP results in milder desorption conditions during affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins, especially those which tolerate modification of the 2'-ribose hydroxyl group such as some phosphodiesterases. This type of gel is offered with a longer spacer (Rp-2'-AHC-cAMPS-Agarose, Cat. No. A 049) as well. Detailed technical information available.
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.

Cat. No. A 126
CAS number [pending]
Storage temperature 4°C / 39°F
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 2'-cAMP