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Alternative structural projections:

8-NBD-cAMP

8- (2- [7- Nitro- 4- benzofurazanyl]aminoethylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-NBD-cAMP ), sodium salt
Fluorescent cyclic AMP analogue
Cat. No.: N 002
    
CAS No.: [221905-51-7]
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Product Name Price (net) Qty
Cat. No.: N 002-01
Unit: 1 µmol / ~0.6 mg
$207.00
For other salt forms or metabolites please inquire. Potent membrane-permeant fluorescent activator (λexc 471 nm, λem 536 nm) of cAMP-dependent protein kinase. While 8-NBD-cAMP is almost non-fluorescent in aqueous solutions, it fluoresces strongly in hydrophobic environments such as hydrophobic protein binding sites. Detailed technical information available. Reference: Kraemer et al., J. Mol. Biol., 306, 1167 - 1177 (2001); Wu et al., Biophys. J., 100, 1226- 1232 (2011); Chen et. al., Bioorg. Med. Chem. Lett., 22, 4038 - 4043 (2012).
Cat. No. N 002
CAS number [221905-51-7]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₈H₁₇N₉O₉PS · Na
Molecular weight [g/mol] 589.4
Modifications 8-cAMP
Target PKA (cAK) Activator
Excitation max [nm] 471
Emission max [nm] 536
Lipophilicity 2.24
Absorption max [nm] 463
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 22000
Solvent for UV data MeOH
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  • 8. Kraemer A., Rehmann H., Cool R. H., Theiss C., de Rooij J., Bos H.Wittinghofer A., J. Mol. Biol., 306, 1167 - 1177 (2001), "Dynamic Interaction of cAMP with the Rap Guanine-nucleotide Exchange Factor Epac1"