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c[G(2',5')pA(3',5')p] / 2'3'-cGAMP

Cyclic (guanosine- (2' −> 5')- monophosphate- adenosine- (3' −> 5')- monophosphate) ( c[G(2',5')pA(3',5')p] / cGAMP(2'-5') / 2'3'-cGAMP / 2',5'-3',5'-cGAMP ), sodium salt
Metazoan cyclic dinucleotide second messenger
Cat. No.: C 161
    
CAS No.: [1441190-66-4]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 161-005
Unit: 0.5 µmol / ~337 µg
$150.00

For other salt forms please inquire.c[G(2',5')pA(3',5')p] was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). It has also been reported to exert potent activation of the immune signalling protein STING. Detailed technical information available. References: Gao et al., Cell, 153, 1094 - 1107 (2013); Ablasser et al., Nature, 498, 380 - 384 (2013); Zhang et al., Mol. Cell, 51, 226 - 235 (2013); Diner et al., Cell Rep., 3, 1355 - 1361 (2013).

Related products: Biolog also offers the potential bacterial second messenger c[G(3',5')pA(3',5')p] (c-(ApGp), Cat. No. C 117).

Cat. No. C 161
CAS number [1441190-66-4]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₃P₂ (free acid)
Molecular weight [g/mol] 674.4 (free acid)
Absorption max [nm] 256
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 25050