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8-AHA-2'-O-Me-cAMP

8- (6- Aminohexyl)amino- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-AHA-2'-O-Me-cAMP )
Epac agonist functionalized for immobilization or conjugation with markers and dyes
Cat. No.: A 099
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: A 099-05
Unit: 5 µmol / 2.3 mg
$248.00

8-AHA-2'-O-Me-cAMP has only poor affinity towards protein kinases A and G and is thus suitable as a ligand in affinity chromatography of cAMP binding proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases. Detailed technical information available.

Cat. No. A 099
Patent Information Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
CAS number [pending]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₂₈N₇O₆P
Molecular weight [g/mol] 457,4
Modifications 8-cAMP, 2'-cAMP
Target Epac Activator
Lipophilicity 1.69
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Hanke S. E., Bertinetti D., Badel A., Schweinsberg S., Genieser H.-G.Herberg F. W., N. Biotechnol., 28, 294 - 301 (2011), "Cyclic Nucleotides as Affinity Tools: Phosphorothioate cAMP Analogues Adress Specific PKA Subproteomes"
  • 2. Borland G., Gupta M., Magiera M. M., Rundell C. J., Fuld S.Yarwood S. J., Mol. Pharmacol., 69, 374 - 384 (2006), "MAP1B-LC1 Enhances Activation of Rap1 by Exchange Protein Activated by Cyclic AMP (EPAC) but not Intracellular Targeting"