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TNP-GTP

2', 3'- O- (2, 4, 6- Trinitrophenyl)guanosine- 5'- O- triphosphate ( TNP-GTP ), sodium salt
Fluorescent analogue of GTP
Cat. No.: T 026
    
CAS No.: [612837-26-0]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: T 026-01
Unit: 1 µmol / ~0.7 mg
$120.00

For other salt forms please inquire. Fluorescent analogue of GTP with λexc 408 nm and λem 552 nm, which can substitute for GTP in the interaction with various enzymes and proteins. It is sensitive to indicators of local environment such as polarity and viscosity, and frequently exhibits a spectral shift and fluorescence enhancement upon binding to a protein. Inhibitor of soluble guanylyl cyclase (sGC). Detailed technical information available. References: Hiratsuka, T., J. Biol. Chem., 260, 4784 - 4790 (1985); Suryanarayana et al., J. Pharmacol. Exp. Ther., 330, 687 - 695 (2009).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 8

Cat. No. T 026
CAS number [612837-26-0]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 8
Storage temperature -70°C / -94°F
Light-sensitive True
Molecular formula C₁₆H₁₇N₈O₂₀P₃ (free acid)
Molecular weight [g/mol] 734,3 (free acid)
Excitation max [nm] 408
Emission max [nm] 552
Absorption max [nm] 408
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 26500
UV pH value 8
  • 1. Suryanarayana S., G�ttle M., H�bner A., Gille A., Mou T.-C., Sprang S. R., Richter M.Seifert R., J. Pharmacol. Exp. Ther., 330, 687 - 695 (2009), "Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2',3'-O-(2,4,6-Trinitrophenyl)-substituted Nucleoside 5'-triphosphates"
  • 2. Hiratsuka T., Eur. J. Biochem., 270, 3479 - 3485 (2003), "Fluorescent and Colored Trinitrophenylated Analogs of ATP and GTP"
  • 3. Virginio C., Robertson G., Surprenant A.North R. A., Mol. Pharmacol., 53, 969 - 973 (1998), "Trinitrophenyl-substituted Nucleotides are Potent Antagonists Selective for P2X1, P2X3, and heteromeric P2X2/3 Receptors"
  • 4. Hiratsuka T., J. Biol. Chem., 260, 4784 - 4790 (1985), "A Chromophoric and Fluorescent Analog of GTP, 2',3'-O-(2,4,6-Trinitrocyclohexadienylidene)-GTP, as a Spectroscopic Probe for the GTP Inhibitory Site of Liver Glutamate Dehydrogenase"