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Rp-8-AHA-cAMPS

8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-AHA-cAMPS )
The PKA inhibitor Rp-cAMPS functionalized for immobilization or conjugation with markers and dyes
Cat. No.: A 085
    
CAS No.: [214272-02-3]
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Product Name Price (net) Qty
Cat. No.: A 085-05
Unit: 5 µmol / ~2.3 mg
$363.00
nalogue of the PKA inhibitor Rp-cAMPS, suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases or proteinkinase A) or for coupling of various labeling structures including fluorophores. PDE-resistant form of 8-AHA-cAMP, Cat. No. A 011. Detailed technical information available. Reference: Stokka et al., Biochem. J., 400, 492 - 499 (2006).
Cat. No. A 085
CAS number [214272-02-3]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₆N₇O₅PS
Molecular weight [g/mol] 459,5
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 8-cAMP
Target PKA (cAK) Inhibitor
Lipophilicity 1.45
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Bertinetti D., Schweinsberg S., Hanke S. E., Schwede F., Bertinetti O., Drewianka S., Genieser H.-G.Herberg F. W., BMC Chem Biol, 9, 0 - 0 (2009), "Chemical tools selectively target components of the PKA system"
  • 2. Schweinsberg S., Moll D., Burghardt N. C., Hahnefeld C., Schwede F., Zimmermann B., Drewianka S., Werner L., Kleinjung F., Genieser H.-G., Schuchhardt J.Herberg F. W., Proteomics, 8, 1212 - 1220 (2008), "Systematic interpretation of cyclic nucleotide binding studies using KinetXBase"
  • 3. Stokka A. J., Gesellchen F., Carlson C. R., Scott J. D., Herberg F. W.Tasken K., Biochem. J., 400, 493 - 499 (2006), "Characterization of A-kinase-anchoring Disruptors Using a Solution-based Assay"