C₁₆H₂₆N₇O₆P; MW 443.4; λ_max 273 nm; ε 17000; free acid; purity > 98% HPLC. Site selective cAMP analogue with preference for site B of R I of cAMP-dependent protein kinase. In combination with 8-PIP-cAMP (Cat. No. P 002), which selects site A of R I and site B of R II specific synergistic activation of kinase type I can be obtained. Reference: Skalhegg et al., J. Biol. Chem., 267, 15707 - 15714 (1992). Also suitable as a ligand in affinity chromatography (8-AHA-cAMP-Agarose; Cat. No. A 028) or surface plasmon resonance chip technology (Herberg et al., J. Mol. Biol., 298, 329 - 339 (2000); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006)) and for modification with fluorophores. Detailed technical information and selected references available.