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Alternative structural projections:


2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-O-MB-cAMPS ), sodium salt
Metabolically activatable Form of the PKA inhibitor Rp-cAMPS
Cat. No.: M 004
CAS No.: [152218-23-0]
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Cat. No.: M 004-05
Unit: 5 µmol / ~2.2 mg
Lipophilic precursor of Rp-cAMPS (Cat. No. A 002), a competitive inhibitor of protein kinase A. During metabolic activation by esterases the inhibitor and butyrate are released. Caution: Butyrate was shown to have distinct biological effects! Significantly more lipophilic and membrane-permeant compared to Rp-cAMPS. Resistant against mammalian phosphodiesterases. Detailed technical information and updated reference available for Rp-cAMPS on request. Reference: Vischer et al., Blood, 91, 118 - 127 (1998); Ouyang et al., Proc. Natl. Acad. Sci. USA, 105, 11993 - 11997 (2008).
Cat. No. M 004
CAS number [152218-23-0]
Purity > 97% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₄H₁₇N₅O₆PS · Na
Molecular weight [g/mol] 437,4
cAMP modified at the exocyclic oxygen equatorial (Rp-)
Modifications 2'-cAMP
Lipophilicity 2.15
Absorption max [nm] 258
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15200