C₁₀H₁₁N₅O₆PS^.Na; MW 383.3; λ_max 252 nm; ε 13500; sodium salt, purity > 99% HPLC. For other salt forms please inquire. Inhibitor of protein kinase G Iα. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Caution: Both membrane permeability and kinase specificity of this analogue are low. Rp-8-pCPT-cGMPS (Cat. No. C 013) or Rp-8-Br-PET-cGMPS (Cat. No. P 007) are much more permeant and selective antagonists! In order to avoid disappointments, please use for permeabilized cells or injection techniques only and make sure that lacking cAMP/cGMP specificity is not a problem. Useful of course for in vitro kinase and phosphodiesterase mapping studies! Detailed technical information and updated reference list available on request. Reference: Butt et al., FEBS Lett., 263, 47 - 50 (1990).

Protected under patent DE 3802865.4 exclusively licensed to BIOLOG LSI