Basket (0 Items) - Amount: 0.00$8- Bromo- ß- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-PET-cGMPS )
Membrane-permeant and PDE-resistant PKG inhibitor
Cat. No.: P 007 CAS No.: [172806-20-1]
C18H14BrN5O6PS•Na; MW 562.3; λmax 256 nm; ε 40000; sodium salt, purity > 99% HPLC. For other salt forms please inquire. Selective and membrane-permeant inhibitor of both cyclic GMP dependent protein kinase I a and I ß and of retinal cGMP-gated ion channels. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. More lipophilic and membrane-permeant compared to Rp-8-pCPT-cGMPS (Cat. No. C 013). Detailed technical information and updated reference list available on request. Reference: Butt et. al., Br. J. Pharmacol., 116, 3110 - 3116 (1995).
Protected under patents US 5,625,056, DE 42 17679 & DE 3802865.4 issued or licensed exclusively to BIOLOG LSI
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