N2, 2'- O- Dibutyrylguanosine- 3', 5'- cyclic monophosphate ( DB-cGMP )

Metabolically activatable PKG agonist
Cat. No.: D 010   CAS No.: [51116-00-8]   Bulk available
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C18H23N5O9P•Na; MW 507.4; λmax 256 nm; ε 16700; sodium salt; purity > 97% HPLC. For other salt forms please inquire. Caution: We do not recommend this cGMP analogue due to its lacking potency and selectivity. The metabolically released N2-monobutyryl cGMP is only a poor activator of cGMP- dependent protein kinase, and released butyrate can have its own side effects leading to misinterpretation of experimental results. Ref.: Butt et al., Biochem. Pharmacol., 43, 2591 - 2600 (1992). We offer numerous more recommendable cGMP agonists; e.g. 8-pCPT-cGMP (Cat. No. C 009), is a much better choice. Detailed technical information available.

 



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