Basket (0 Items) - Amount: 0.00$8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate ( 8-pCPT-cGMP ), fluorescence grade
Membrane-permeant PKG agonist
Cat. No.: C 009 CAS No.: [51239-26-0] Bulk available
C16H14ClN5O7PS•Na; MW 509.8; λmax 276 nm; ε 21500; sodium salt, purity > 99% HPLC; specially purified quality, fluorescent impurities removed. For other salt forms please inquire. Selective activator of both, cGMP-dependent protein kinase type I α and type II, as well as of cGMP-gated ion channels. Higher activation potential compared to cGMP; excellent cell membrane permeability and stability towards many phosphodiesterases. Recommendable alternative to unsuitable analogues such as dibutyryl cGMP. Detailed technical information and updated reference list available on request. Reference: Geiger et al., Proc. Natl. Acad. Sci. USA, 89, 1031 - 1035 (1992). 8-pCPT-cGMP is also available in an inexpensive, normal quality form (C 009 Economy Grade) and as bulk ware.
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