Adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-cAMPS ), economy grade
C10H11N5O5PS•C6H16N; MW 446.5; λmax 258 nm; ε 15000; triethyl ammonium salt; purity > 98% HPLC. This product corresponds to normal quality offered elsewhere. Sp-cAMPS is also available in a highly purified form as sodium salt (Cat. No. A 003 S). Activator of protein kinase A (cyclic AMP agonist). Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl or 8-Br-cAMP, no metabolic side effects. Membrane permeability comparable to 8-Br-cAMP. Detailed technical information and updated reference list available on request. Reference: Tsien et al.: J. Cell Biol., 117, 57 - 72 (1992). Sp-cAMPS is also available with functionalized spacers in positions 2, 6, 8 and 2', as well as correspondingly immobilized to affinity gels. Protected under patent DE 3802865.4 exclusively licensed to BIOLOG LSI
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