Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-cAMPS
. Metabolic bioactivation by esterases releases the active analogue, which is trapped inside the cell. Chemical hydrolysis can produce some cyclic AMP as well. Detailed technical information available. Reference: Maronde et al., J. Pineal Res
, 183 - 185 (2001). Vanhoose et al., J. Neurosci
, 1138 - 1145 (2006). Biolog also offers Phosphate tris(acetoxymethyl)ester
, Cat. No. P 030
) which is recommended as control reagent in nucleotide-AM ester applications.