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Alternative structural projections:


Adenosine- 3', 5'- monophosphorothioate acetoxymethyl ester, Sp- isomer (Sp-cAMPS-AM)
Metabolically activatable prodrug of the PDE-resistant PKA agonist Sp-cAMPS
Cat. No.: A 035
CAS No.: [152218-24-1]
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Cat. No.: A 035-01
Unit: 1 µmol / ~0.4 mg
Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-cAMPS. Metabolic bioactivation by esterases releases the active analogue, which is trapped inside the cell. Chemical hydrolysis can produce some cyclic AMP as well. Detailed technical information available. Reference: Maronde et al., J. Pineal Res., 31, 183 - 185 (2001). Vanhoose et al., J. Neurosci., 26, 1138 - 1145 (2006). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. A 035
CAS number [152218-24-1]
Purity > 97% HPLC for mixture of the axial and equatorial isomer
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₆N₅O₇PS
Molecular weight [g/mol] 417,3
Target PKA (cAK) Activator
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15200