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cUMP-AM

Uridine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cUMP-AM )
Highly membrane-permeant prodrug form of cyclic UMP
Cat. No.: U 012
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: U 012-01
Unit: 1 µmol / ~0.4 mg
$178.00
Membrane-permeant, metabolically activatable prodrug form of the potential further second messenger cyclic UMP (cUMP, Cat. No. U 001). After permeation and metabolic activation by esterases the polar cUMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal. Detailed technical information available. Reference: Beckert et al., Biochem. Biophys. Res. Commun., 451, 497 - 502 (2014).
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. U 012
CAS number [pending]
Purity > 95% HPLC for mixtures of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₅N₂O₁₀P
Molecular weight [g/mol] 378,2
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 10000
  • 1. Wolter S., Kloth C., Golombek M., Dittmar F., Försterling L.Seifert R., Biochem. Pharmacol., 98, 119 - 131 (2015), "cCMP Causes Caspase-dependent Apotosis in Mouse Lymphoma Cell Lines"
  • 2. Beckert U., Grundmann M., Wolter S., Schwede F., Rehmann H., Kaever V., Kostenis E.Seifert R., Biochem. Biophys. Res. Commun., 451, 497 - 502 (2014), "cNMP-AMs Mimic and Dissect Bacterial Nucleotidyl Cyclase Toxin Effects"