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c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS

Cyclic (adenosine- (2' −> 5')- monophosphorothioate[Rp]- adenosine- (3' −> 5')- monophosphorothioate[Rp]) ( c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS ), sodium salt

Di-thiophosphate analogue of 2'3'-c-diAMP and STING ligand
Cat. No.: C 224
    
CAS No.: [1638750-95-4]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 224-001
Unit: 0.1 µmol / ~69 µg
$286.00

For other salt forms please inquire. c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] is a synthetic cyclic dinucleotide with improved stability against degradation by phosphodiesterases. It has enhanced binding affinity to STING and activates mouse STING (mSTING) as well as all known human STING (hSTING) alleles. Compared to natural cyclic dinucleotides such as c-diGMP (BIOLOG Cat. No. C 057) or c[G(2',5')pA(3',5')p] (2'3'-cGAMP, BIOLOG Cat. No. C 161), c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] shows higher potency in inducing interferons. In addition, it was found to generate anti-cancer effects in mouse models of solid tumors and acute myeloid leukemia (AML) (all data according to Corrales et al. (2015), Fu et al. (2015), Curran et al. (2016)). References: Corrales et al., Cell Rep., 11, 1018 - 1030 (2015); Fu et al., Sci. Transl. Med., 7, 283:283ra52 (2015); Curran et al., Cell Rep., 15, 2357 - 2366 (2016).

Cat. No. C 224
CAS number [1638750-95-4]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₀P₂S₂ (free acid)
Molecular weight [g/mol] 690,6 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27350