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Alternative structural projections:

8-[Fluo]-cGMP

8- (2- [Fluoresceinyl]aminoethylthio)guanosine- 3', 5'- cyclic monophosphate ( 8-[Fluo]-cGMP / 8-[Fluo]-AET-cGMP ), sodium salt
Fluorescent cyclic GMP analogue
Cat. No.: F 001
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: F 001-01
Unit: 1 µmol / ~0.8 mg
$138.00
For other salt forms or metabolites please inquire. Fluorescent cGMP analogue (λexc 494 nm, λem 517 nm). A similar compound has been described to be the most potent channel activator tested so far: Tanaka et al., Biochemistry, 28, 2776 - 2784 (1989). Detailed technical information available. References: Pena & Dominquez, J. biol. Screen., 15, 1281 - 1286 (2010); Lolicato et al., J. Biol. Chem., 286, 44811 - 44820 (2011).
Cat. No. F 001
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₃₃H₂₇N₇O₁₂PS₂ · Na
Molecular weight [g/mol] 831,7
Modifications 8-cGMP
Target PKG (cGK) Activator
Excitation max [nm] 494
Emission max [nm] 517
Lipophilicity 2.41
Absorption max [nm] ~494
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] ~79000
UV pH value 9
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  • 2. Pena I.Dominguez J. M., J Biomol Screen., 15, 1281 - 1286 (2010), "Thermally Denatured BSA, a Surrogate Additive to Replace BSA in Buffers for High-Throughput Screening"
  • 3. Brown R. L., Strassmaier T., Brady J. D.Karpen J. W., Curr. Pharmaceut. Design, 12, 3597 - 3613 (2006), "The Pharmacology of Cyclic Nucleotide-Gated Channels: Emerging from the Darkness"
  • 4. Christensen A. E.Doeskeland S. O., Handbook of Cell Signaling Academic Press/Elsevier Science San Diego CA, 2, 549 - 554 (2003), "Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling"
  • 5. Reymond C. D., , 0, 0 - 0 (2003), "Use of the Regulatory Subunit of the cAMP Dependent Protein Kinase (PKA) from Dictyostelium for cAMP Measurements"
  • 6. Kuethe A., Maronde E., Forssmann W.-G.Stief C. G., Pharmacol. Ther., 51, 13 - 33 (2000), "Detection of cGMP-Binding Proteins in Human Corpus Cavernosum"
  • 7. Scott S.-P.Tanaka J. C., Biochemistry, 34, 2338 - 2347 (1995), "Molecular Interactions of 3',5'-Cyclic Purine Analogues with the Binding Site of Retinal Rod Ion Channels"
  • 8. Olson A.Pugh E. N., Biophys. J., 65, 1335 - 1352 (1993), "Diffusion Coefficient of Cyclic GMP in Salamander Rod Outer Segments Estimated with Two Fluorescent Probes"
  • 9. Tanaka J. C., Eccleston J. F.Furman R. E., Biochemistry, 28, 2776 - 2784 (1989), "Photoreceptor Channel Activation by Nucleotide Derivatives"
  • 10. Pusch M.Neher E., Pflugers Arch. Eur. J. Physiol., 411, 204 - 211 (1988), "Rates of Diffusional Exchange between Small Cells and a Measuring Patch Pipette"
  • 11. Ruf H. H., Rack M., Landgraf W.Hofmann F., in L.M.G. Heilmeyer: Signal Transduction and Protein Phosphorylation NATO ASI Series A: Life Sciences, 135, 99 - 104 (1987), "Binding of Fluorescent Analogs of Cyclic GMP to cGMP-dependent Protein Kinase"