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8-Cl-Ino

8- Chloroinosine ( 8-Cl-Ino )
Potential metabolite of 8-Cl-cAMP
Cat. No.: C 019
    
CAS No.: [116285-77-9]
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Product Name Price (net) Qty
Cat. No.: C 019-05
Unit: 5 µmol / ~1.5 mg
$121.00
Potential metabolite of 8-chloro cyclic AMP (Cat. No. C 007) and 8- chloroadenosine (Cat. No. C 006), respectively. Detailed technical information available. Reference: Lange-Carter et al., Cancer Res., 53, 393 - 400 (1993).
This compound is also part of the Ko-Libri compound library (K 001)
Cat. No. C 019
CAS number [116285-77-9]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₁ClN₄O₅
Molecular weight [g/mol] 302,7
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 10500
  • 1. Gandhi V., Chen W., Ayres M., Rhie J. K., Madden T. L.Newman R. A., Cancer Chemother. Pharmacol., 50, 85 - 94 (2002), "Plasma and Cellular Pharmacology of 8-Chloro-Adenosine in Mice and Rats"
  • 2. Gandhi V., Ayres M., Halgren R. G., Krett N. L., Newman R. A.Rosen S. T., Cancer Res., 61, 5474 - 5479 (2001), "8-Chloro-cAMP and 8-Chloro-Adenosine Act by the Same Mechanism in Multiple Myeloma Cells"
  • 3. Kozlowska M., Smolenski R. T., Makarewicz W., Hoffmann C., Jastorff B.Swierczynski J., Toxicol. Lett., 104, 171 - 181 (1999), "ATP Depletion, Purine Riboside Triphosphate Accumulation and Rat Thymocyte Death Induced by Purine Riboside"
  • 4. Han Z. Y., Chatterjee D., Early J., Pantazis P., Hendrickson E. A.Wyche J. H., Cancer Res., 56, 1621 - 1628 (1996), "Isolation and Characterization of an Apoptosis-Resistant Variant of Human Leukemia HL-60 Cells that has Switched Expression from Bcl-2 to Bcl-X(L)"
  • 5. Vintermyr O. K., Böe R., Brustugun O. T., Maronde E., Aakvaag A.Doeskeland S. O., Endocrinology, 136, 2513 - 2520 (1995), "Cyclic Adenosine Monophosphate (cAMP) Analogs 8-Cl- and 8-NH(2)-cAMP Induce Cell Death Independently of cAMP Kinase-Mediated Inhibition of the G(1)/S Transition in Mammary Carcinoma Cells (MCF-7)"
  • 6. Langeveld C. H., Jongenelen C. A. M., Heimans J. J.Stoof J. C., Cancer Res., 52, 3994 - 3999 (1992), "Growth Inhibition of Human Glioma Cells Induced by 8-Chloroadenosine, an Active Metabolite of 8-Chloro Cyclic Adenosine 3':5'- Monophosphate"
  • 7. Lange-Carter C. A., Vuillequez J. J.Malkinson A. M., Cancer Res., 53, 393 - 400 (1992), "8-Chloroadenosine Mediates 8-Chloro-Cyclic AMP-Induced Down- Regulation of Cyclic AMP-dependent Protein Kinase in Normal and Neoplastic Mouse Lung Epithelial Cells by a Cyclic AMP-independent Mechanism"
  • 8. Han Z., Chatterjee D.Wyche J. H., J. Pharmacol. Exp. Ther., 265, 790 - 794 (1992), "Proliferation of Nontransformed Cells is Inhibited by Adenosine Metabolite of But Not by Parental 8-Cl-Cyclic AMP"