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Alternative structural projections:

8-AET-cGMP

8- (2- Aminoethylthio)guanosine- 3', 5'- monophosphate
cyclic GMP functionalized for conjugation with markers and dyes or for immobilization
Cat. No.: A 029
    
CAS No.: [115974-70-4]
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Product Name Price (net) Qty
Cat. No.: A 029-05
Unit: 5 µmol / ~2.1 mg
$121.00
Suitable as a ligand in affinity chromatography (compare Cat. No. A 019) and for modification with fluorophores or other markers. Detailed technical information and references available. Reference: Dills et al., Biochemistry, 15, 3724 - 3730 (1976); Jäger et al., Br. J. Pharmacol., 161, 1645 - 1660 (2010).
Cat. No. A 029
CAS number [115974-70-4]
Purity > 98% HPLC
Salt form free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₇N₆O₇PS
Molecular weight [g/mol] 420.4
Modifications 8-cGMP
Target PKG (cGK) Activator
Lipophilicity 0.93
Absorption max [nm] 272
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14000
  • 1. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 2. Brown R. L., Bert R. J., Evans F. E.Karpen J. W., Biochemistry, 32, 10089 - 10095 (1993), "Activation of Retinal Rod cGMP-Gated Channels: What Makes for an Effective 8-Substituted Derivative of cGMP?"
  • 3. Dills W. L., Beavo J. A., Bechtel P. J., Myers K. R., Sakai L. J.Krebs E. G., Biochemistry, 15, 3724 - 3731 (1976), "Binding of Adenosine 3', 5'- Monophosphate Dependent Protein Kinase Regulatory Subunit to Immobilized Cyclic Nucleotide Derivatives"