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Sp-GDP-α-S

Guanosine- 5'- O- (1- thiodiphosphate), Sp- isomer ( Sp-GDP-α-S ), sodium salt
Cat. No.: G 013
    
CAS No.: [71481-45-3]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: G 013-05
Unit: 5 µmol / ~2.3 mg
$252.00

For other salt forms please inquire. Modulator of GDP binding proteins with often increased metabolic stability. Useful for characterization of GDP-responsive receptors and determination of their stereospecificity. Detailed technical information available. References: Yamanaka et al., Biochemistry, 24, 8094 - 8101 (1985); Tucker et al., EMBO J., 5, 1351 - 1358 (1986).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. G 013
CAS number [71481-45-3]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₅N₅O₁₀P₂S (free acid)
Molecular weight [g/mol] 459,3 (free acid)
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300
  • 1. He K., Porter K. W., Hasan A., Briley J. D.Ramsay Shaw B., Nucleic Acids Res., 27, 1788 - 1794 (1999), "Synthesis of 5-Substituted 2'-Deoxycytidine 5'-(alpha-P-Borano)Triphosphates, their Incorporation into DNA and Effects on Exonuclease"
  • 2. Tucker J., Sczakiel G., Feuerstein J., John J., Goody R. S.Wittinghofer A., EMBO J., 5, 1351 - 1358 (1986), "Expression of p21 Proteins in Escherichia coli and Stereochemistry of the Nucleotide-binding Site"
  • 3. Goody R. S.Isakov M., Tetrahedron Lett., 27, 3599 - 3602 (1986), "Simple Synthesis and Separation of the Diastereomers of alpha-Thio Analogs of Ribo- and Deoxyribo-di- and Triphosphates"
  • 4. Lee M. H., Goody R. S.Nowak T., Biochemistry, 24, 7594 - 7602 (1985), "Guanosine Thiophosphate Derivatives as Substrate Analogues for Phosphoenolpyruvate Carboxykinase"
  • 5. Yamanaka G., Eckstein F.Stryer L., Biochemistry, 24, 8094 - 8101 (1985), "Stereochemistry of the Guanyl Nucleotide Binding Site of Transducin Probed by Phosphorothioate Analogues of GTP and GDP"
  • 6. Tomasselli A. G., Marquetant R., Noda L. H.Goody R. S., Eur. J. Biochem., 142, 287 - 289 (1984), "The Use of Phosphorothioate Diastereomers to Define the Structure of Metal-nucleotide Bound to GTP-AMP and ATP-AMP Phosphotransferase from Beef-heart Mitochondria"
  • 7. Senter P. D., Eckstein F., Mülsch A.Böhme E., J. Biol. Chem., 258, 6741 - 6745 (1983), "The Stereochemical Course of the Reaction Catalyzed by Soluble Bovine Lung Guanylate Cyclase"
  • 8. Marquetant R.Goody R. S., J. Chromatogr., 280, 386 - 389 (1983), "An Improved Separation of Diastereomers of Nucleoside Phosphorothioates Using Reversed-phase High-Performance Liquid Chromatography"
  • 9. Goody R. S.Leberman R., FEBS Lett., 102, 269 - 272 (1979), "The Preparation of Thiophosphate Analogs of GDP and their Interaction with EF-Tu"