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Rp,Rp-c-diAMPSS

Cyclic diadenosine monophosphorodithioate, Rp- isomers ( Rp,Rp-c-diAMPSS ), sodium salt
Di-thiophosphate analogue of c-diAMP
Cat. No.: C 118
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 118-001
Unit: 0.1 µmol / ~69 µg
$286.00

For other salt forms please inquire. Sulfur-modified analogue of the bacterial second messenger c-diAMP (Cat. No. C 088) with increased metabolic stability. Rp,Rp-c-diAMPSS can be useful in studies on ligand-receptor interactions and was reported to enhance the anti-tumor activity of therapeutic vaccines. Detailed technical information available. Reference: Leong et al., J. Immunother. Cancer, 1(Suppl. 1): O20 (2013).

Cat. No. C 118
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₀P₂S₂ (free acid)
Molecular weight [g/mol] 690,6 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27000
  • 1. Leong M., Kanne D., Glickman L., Lemmens E., Lauer P., Metchette K., Burdette D., Diner E., Fu J., Soares K., Brockstedt D., Portnoy D. A., Vance R. E., Kim Y., Jaffee E., Pardoll D.Dubensky T., J. Immunother. Cancer (Suppl 1):O20, 1, 0 - 0 (2013), "Modified STING-activating Cyclic Dinucleotide Derivatives Significantly Enhance the Anti-Tumor Activity of Therapeutic Vaccines"