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Rp-GTP-α-S

Guanosine- 5'- O- (1- thiotriphosphate), Rp isomer ( Rp-GTP-α-S ), sodium salt
Cat. No.: G 014
    
CAS No.: [81570-50-5]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: G 014-05
Unit: 5 µmol / ~2.7 mg
$252.00

For other salt forms or a guaranteed higher purity please inquire.
Modulator of GTP binding proteins with often increased metabolic stability. Useful for characterization of GTP-responsive receptors and determination of their stereospecificity. Detailed technical information available. References: Koch et al., J. Biol. Chem., 265, 9659 - 9663 (1990); Von zur Muehlen et al., Int. Arch. Allergy Appli. Immunol., 94, 74 - 75 (1991).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. G 014
CAS number [81570-50-5]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₆N₅O₁₃P₃S (free acid)
Molecular weight [g/mol] 539,3 (free acid)
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14300
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  • 3. Schaertl S., Konrad M.Geeves M. A., J. Biol. Chem., 273, 5662 - 5669 (1998), "Substrate Specificity of Human Nucleoside-diphosphate Kinase Revealed by Transient Kinetic Analysis"
  • 4. Koch K. W., Eckstein F.Stryer L., J. Biol. Chem., 265, 9659 - 9663 (1996), "Stereochemical Course of the Reaction Catalyzed by Guanylate Cyclase from Bovine Retinal Rod Outer Segments"
  • 5. Von zur Muehlen F.Penner R., Int. Arch. Allergy Appl. Immunol., 94, 74 - 75 (1991), "A GTP Analog Induces Calcium Release But Not Secretion in Rat Mast Cells"
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  • 8. Lee M. H., Goody R. S.Nowak T., Biochemistry, 24, 7594 - 7602 (1985), "Guanosine Thiophosphate Derivatives as Substrate Analogues for Phosphoenolpyruvate Carboxykinase"
  • 9. Yamanaka G., Eckstein F.Stryer L., Biochemistry, 24, 8094 - 8101 (1985), "Stereochemistry of the Guanyl Nucleotide Binding Site of Transducin Probed by Phosphorothioate Analogues of GTP and GDP"
  • 10. Tomasselli A. G., Marquetant R., Noda L. H.Goody R. S., Eur. J. Biochem., 142, 287 - 289 (1984), "The Use of Phosphorothioate Diastereomers to Define the Structure of Metal-nucleotide Bound to GTP-AMP and ATP-AMP Phosphotransferase from Beef-heart Mitochondria"
  • 11. Marquetant R.Goody R. S., J. Chromatogr., 280, 386 - 389 (1983), "An Improved Separation of Diastereomers of Nucleoside Phosphorothioates Using Reversed-phase High-Performance Liquid Chromatography"
  • 12. Rösch P., Kalbitzer H. R.Goody R. S., FEBS Lett., 121, 211 - 214 (1980), "31P-NMR Spectra of Thiophosphate Analogues of Guanosine Nucleotides"