8- (4- Methoxyphenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-pMeOPT-2'-O-Me-cAMP )
C18H19N5O7PS•Na; MW 503.4; λmax 282 nm; ε 16000; sodium salt; purity > 98% HPLC. For other salt forms please inquire. Very potent and specific activator of the exchange protein activated by cyclic AMP (Epac) or cAMP-GEF, respectively, which does not activate protein kinase A. High lipophilicity and membrane permeability, as well as increased PDE stability. Detailed technical information and updated references available. References: Christensen et al., J. Biol. Chem., 278, 35394 - 35402 (2003); Holz et al., J. Physiol., 577, 5 – 15 (2006).
Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
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