Basket (0 Items) - Amount: 0.00$(7- Dimethylaminocoumarin-4- yl)methyl- 8- bromoguanosine- 3', 5'- cyclic monophosphate ( DMACM-caged 8-Br-cGMP )
Caged 8-Br-cGMP releasing fluorescent coumarin upon irradiation
Cat. No.: D 045
C22H22BrN6O9P x 0.5 H2O; MW 634.3; λmax 398 nm; ε 16000; purity > 98% HPLC. Axial isomer, for the corresponding isomeric mixture please inquire. DMACM-caged 8-Br-cGMP is an only weakly fluorescent, caged precursor of 8-bromo cyclic cGMP, which upon irradiation, releases both 8-Br-cGMP and a strongly fluorescent coumarin analogue. High lipophilicity and membrane permeability, thus only limited solubility in aqueous systems. Detailed technical information available. For similar approach please compare: Hagen et al., J. Photochem. Photobiol. B: Biol., 53 (1999).
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