Basket (0 Items) - Amount: 0.00$8- (4- Chlorophenylthio)- ß- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-PET-cGMPS )
Highly membrane-permeant, PDE-resistant PKG agonist
Cat. No.: C 047 CAS No.: [pending]
C24H18ClN5O6PS2•Na; MW 626.0; λmax 276 nm; ε 40000; sodium salt, purity > 99% HPLC. For other salt forms please inquire. Membrane-permeant activator of cyclic GMP-dependent protein kinase, but most probably inhibitor of the retinal type cGMP-gated ion channel, thus suitable for distinction between kinase and ion channel mediated effects. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. More lipophilic and membrane-permeant compared to Sp-8-Br-PET-cGMPS (Cat. No. P 008). Detailed technical information available.
Protected under patents US 5,625,056, DE 42 17679 & DE 3802865.4 issued or licensed exclusively to BIOLOG LSI
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