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DMACM-caged 8-Br-cGMP

(7- Dimethylaminocoumarin- 4- yl)methyl- 8- bromoguanosine- 3', 5'- monophosphate (DMACM-caged 8-Br-cGMP)
Caged 8-Br-cGMP releasing fluorescent coumarin upon irradiation
Cat. No.: D 045
    
CAS No.: pending
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: D 045-001
Unit: 0.1 µmol / ~60 µg
$165.00
Axial isomer, for the corresponding  isomeric mixture please inquire. DMACM-caged 8-Br-cGMP is an only weakly fluorescent, caged precursor of 8-bromo cyclic cGMP, which upon irradiation, releases both 8-Br-cGMP and a strongly fluorescent coumarin analogue. High lipophilicity and membrane permeability, thus only limited solubility in aqueous systems. Detailed technical information available. For similar approach please compare: Hagen et al., J. Photochem. Photobiol. B: Biol., 53 (1999).
Cat. No. D 045
CAS number pending
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₂₂H₂₂BrN₆O₉P
Molecular weight [g/mol] 634,3
Modifications 8-cGMP
Target PKG (cGK) Activator
Absorption max [nm] 398
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
  • 1. Hagen V., Frings S., Wiesner B., Helm S., Kaupp U. B.Bendig J., Chembiochem., 4, 434 - 442 (2003), "[7-(Dialkylamino)Coumarin-4-yl]Methyl-Caged Compounds as Ultrafast and Effective Long-wavelength Phototriggers of 8-Bromo-Substituted Cyclic Nucleotides"