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Sp-cCMPS

Cytidine- 3', 5'- cyclic monophosphorothioate, Sp- isomer
Potential PDE-resistant activator of cCMP-binding proteins
Cat. No.: C 066
    
CAS No.: [87063-81-8]
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Product Name Price (net) Qty
Cat. No.: C 066-05
Unit: 5 µmol / ~1.7 mg
$314.00
For other salt forms please inquire. PDE_resistant, sulfur-modified form of the potential second messenger cyclic CMP and potential activator of cCMP-binding proteins. Detailed technical information available. Reference: Eckstein & Kutzke, Tetrahedr. Lett., 27, 1657 -1660 (1986).
Cat. No. C 066
CAS number [87063-81-8]
Purity > 98% HPLC
Salt form sodium salt
Storage temperature -20°C / -4°F
Molecular formula C₉H₁₁N₃O₆PS · Na
Molecular weight [g/mol] 343.2
Lipophilicity 0.80
Absorption max [nm] 270
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 9000
  • 1. Wolter S., Dove S., Golombek M., Schwede F.Seifert R., Naunyn-Schmiedeberg's Arch. Pharmacol., 387, 1163 - 1175 (2014), "N4-monobutyryl-cCMP Activates PKA RIalpha and PKA RIIalpha more Potently and with Higher Efficacy than PKG Ialpha in Vitro but not in Vivo"
  • 2. Reinecke D., Burhenne H., Sandner P., Kaever V.Seifert R., FEBS Lett., 585, 3259 - 3262 (2011), "Human Cyclic Nucleotide Phosphodiesterases Possess a Much Broader Substrate-Specificity than Previously Appreciated"
  • 3. Eckstein F.Kutzke U., Tetrahedron Lett., 27, 1657 - 1660 (1986), "Synthesis of Nucleoside 3',5'- Cyclic Phosphorothioates"