0 Items - $0.00
Categories
A to Z

c[G(2',5')pS-A(3',5')pS], isomer 1 and isomer 2

Cyclic (guanosine- (2' −> 5')- monophosphorothioate- adenosine- (3' −> 5')- monophosphorothioate) ( c[G(2',5')pS-A(3',5')pS] / 2'3'-cGAMPSS / 2'3'-cGsAsMP ), isomer 1 and isomer 2

Cat. No.: Set 101
    
CAS No.: [1638242-56-4] / [1638243-00-1]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: Set 101-
Unit: 2 x 0.1 µmol
$215.00
For other salt forms please inquire. This set contains 0.1 µmol each of c[G(2',5)pS-A(3',5')pS], isomer 1 and c[G(2',5')pS-A(3',5')pS], isomer 2 which are isomeric di-thiophosphate analogues of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka 2'3'-cGAMP, Cat. No. C 161). c[G(2',5')pS-A(3',5')pS is resistant towards the 2'3'-cGAMP hydrolysing enzyme ENPP1 and shows higher potency than natural 2'3'-cGAMP in inducing IFN-β secretion from human THP1 monocytes. Detailed technical information available. Reference: Li et al., Nat. Chem. Biol., 10, 1043 - 1048 (2014).
Cat. No. Set 101
CAS number [1638242-56-4] / [1638243-00-1]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₄N₁₀O₁₁P₂S₂ (free acid)
Molecular weight [g/mol] 706.6 (free acid)
Absorption max [nm] 256
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 25400
  • 1. Li L., Yin Q., Kuss P., Maliga Z., Millan J. L., Wu H.Mitchison T. J., Nat. Chem. Biol., 10, 1043 - 1048 (2014), "Hydrolysis of 2'3'-cGAMP by ENPP1 and Design of Nonhydrolyzable Analogs"