For other salt forms please inquire. Fluorescent analogue of the metazoan cyclic dinucleotide second messenger and STING activator c[G(2',5')pA(3',5')p] (aka cGAMP(2'-5') or 2'3'-cGAMP, Cat. No. C 161) with λexc 494 nm and λem 517 nm.
c[G(2',5')pA(3',5')p] was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). Detailed technical information available. References for c[G(2',5')pA(3',5')p]: Gao et al., Cell, 153, 1094 - 1107 (2013); Ablasser et al., Nature, 498, 380 - 384 (2013); Zhang et al., Mol. Cell, 51, 226 - 235 (2013); Diner et al., Cell Rep., 3, 1355 - 1361 (2013).
Cat. No. | C 194 |
CAS number | [pending] |
Purity | > 95% HPLC |
Salt form | Sodium |
Storage temperature | -20°C / -4°F |
Light-sensitive | True |
Molecular formula | C₄₈H₄₈N₁₂O₂₀P₂ |
Molecular weight [g/mol] | 1174.9 |
Excitation max [nm] | 494 |
Emission max [nm] | 517 |
Absorption max [nm] | ~494 |
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | ~79000 |
UV pH value | 9 |