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c[8-Br-G(2',5')pA(3',5')p]

Cyclic (8- bromoguanosine- (2' −> 5')- monophosphate- adenosine- (3' −> 5')- monophosphate) ( c[8-Br-G(2',5')pA(3',5')p] ), sodium salt
Mono-functionalized analogue of c[G(2',5')pA(3',5')p] / cGAMP(2'-5')
Cat. No.: C 172
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: C 172-001
Unit: 0.1 µmol / ~75 µg
$225.00
For other salt forms please inquire. Analogue of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka cGAMP(2'-5') or 2'3'-cGAMP, Cat. No. C 161) which may be useful for binding studies and as precursor for further modifications with spacers or labels. c[G(2',5')pA(3',5')p] was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). Detailed technical information available. References for c[G(2',5')pA(3',5')p]: Gao et al., Cell, 153, 1094 - 1107 (2013); Ablasser et al., Nature, 498, 380- 384 (2013); Zhang et al., Mol. Cell, 51, 226 - 235 (2013); Diner et al., Cell Rep., 3, 1355 - 1361 (2013)
Cat. No. C 172
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₃BrN₁₀O₁₃P₂ (free acid)
Molecular weight [g/mol] 753,3 (free acid)
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27800