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ara-2'-F-NAD⁺

β- ara- 2'- Deoxy- 2'- fluoro- nicotinamide adenine dinucleotide ( ara-2'-F-NAD⁺ ), sodium salt
Cat. No.: D 148
    
CAS No.: [133575-27-6]
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Product Name Price (net) Qty
Cat. No.: D 148-001
Unit: 0.1 µmol / ~67 µg
$350.00

For other salt forms or higher purity please inquire. Hydrolysis-resistant slow binding inhibitor of ADP-ribosyl cyclase (i.e. CD 38). Detailed technical information available. References: Muller-Steffner et al., J. Biol. Chem., 267, 9606 - 9611 (1992); Berthelier et al., Biochem. J., 330, 1383 - 1390 (1998); Gerth et al., Biochem. J., 382, 849 - 856 (2004).

Cat. No. D 148
CAS number [133575-27-6]
Purity > 97 % HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₁H₂₆FN₇O₁₃P₂ (free acid)
Molecular weight [g/mol] 665,4 (free acid)
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 20000
  • 1. Gerth A., Nieber K., Oppenheimer N. J.Hauschildt S., Biochem. J., 382, 849 - 856 (2004), "Extracellular NAD+ Regulates Intracellular Free Calcium Concentration in Human Monocytes"
  • 2. Berthelier V., Tixier J.-M., Muller-Steffner H. M., Schuber F.Deterre P., Biochem. J., 330, 1383 - 1390 (1998), "Human CD38 is an Authentic NAD(P)+ Glycohydrolase"
  • 3. Muller-Steffner H. M., Malver O., Hosie L., Oppenheimer N. J.Schubert F., J. Biol. Chem., 267, 9606 - 9611 (1992), "Slow-Binding Inhibition of NAD+ Glycohydrolase by Arabino Analogues of Beta-NAD"
  • 4. Rah S.-Y., Kwak J.-Y.Kim U.-H., Scientific Reports, 0, 0 - 0 (0), "ADP-Ribose/TRM2-mediated Ca2+ Signaling is Essential for Cytolytic Degranulation and Antitumor Activity of Natural Killer Cells"