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Ap₂A / AppA

P¹, P²- Di- (adenosine- 5')- diphosphate ( Ap₂A / AppA ), sodium salt
Cat. No.: D 054
    
CAS No.: [85065-24-3]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: D 054-005
Unit: 0.5 µmol / ~0.3 mg
$245.00

For other salt forms or analogues please inquire. Symmetrical dinucleoside polyphosphate with vasoconstrictor activity. Detailed technical information available. References: Luo et al., FASEB J., 13, 695 - 705 (1999); Lewis et al., Br. J. Pharmacol., 129, 124 - 130 (2000); Pintor et al., J. Pharmacol. Exp. Ther., 304, 342 - 348 (2003).

Cat. No. D 054
CAS number [85065-24-3]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₆N₁₀O₁₃P₂ (free acid)
Molecular weight [g/mol] 676,4 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27000
  • 1. Pintor J., Peral A., Peláez T., Martín S.Hoyle C. H. V., J. Pharmacol. Exp. Ther., 304, 342 - 348 (2003), "Presence of Diadenosine Polyphosphates in the Aqueous Humor: Their Effect on Intraocular Pressure"
  • 2. Haghiac M., Pojoga L. H.Hildermann R. H., Cell Signal., 13, 145 - 150 (2001), "Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells"
  • 3. Lewis C. J., Gitterman D. P., Schlüter H.Evans R. J., Br. J. Pharmacol., 129, 124 - 130 (2000), "Effects of Diadenosine Polyphosphates (Ap(n)As) and Adenosine Polyphospho Guanosines (Ap(n)Gs) on Rat Mesenteric Artery P2X Receptor Ion Channels"
  • 4. Luo J., Jankowski J., Knobloch M., van der Giet M., Gardanis K., Russ T., Vahlensieck U., Neumann J., Schmitz W., Tepel M., Deng M. C., Zidek W.Schlüter H., FASEB J., 13, 695 - 705 (1999), "Identification and Characterization of Diadenosine 5',5''-P1,P2 -Diphosphate and Diadenosine 5',5''-P1,P3-Triphosphate in Human Myocardial Tissue"
  • 5. Chavan A. J., Haley B. E., Volkin D. B., Marfia K. E., Verticelli A. M., Bruner M. W., Draper J. P., Burke C. J.Middaugh C. R., Biochemistry, 33, 7193 - 7202 (1994), "Interaction of Nucleotides with Acidic Fibroblast Growth Factor (FGF- 1)"
  • 6. Mayo K. H., Mvele O. M.Puri R. N., FEBS Lett., 265, 97 - 100 (1990), "Proton Magnetic Resonance Spectroscopic Analysis of Diadenosine 5´,5´´´-polyphosphates"
  • 7. Ikehara M., Uesugi S.Yoshida K., Biochemistry, 11, 836 - 842 (1972), "Conformation of Purine Nucleoside Pyrophophates as Studied by Circular Dichroism"