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8-NO2-Guo

8- Nitroguanosine ( 8-NO2-Guo )
Cat. No.: N 004
    
CAS No.: [337536-53-5]
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Product Name Price (net) Qty
Cat. No.: N 004-05
Unit: 5 µmol / ~1.6 mg
$242.00
Reference for analysis of hydrolysates of RNA stressed by nitric oxide/superoxide and peroxynitrite, respectively. The corresponding nucleobase  is available as well (Cat. No. N 003). Instable, can contain some 8-nitroguanine. For 8-nitro-2'-deoxyguanosine or other 8- nitro nucleosides and nucleotides please inquire. Detailed technical information available. References: Masuda et al., Chem. Biol. Interact., 139, 187 - 197 (2002); Akuta et al., Nitric Oxide, 14, 101 – 108 (2006).
Cat. No. N 004
CAS number [337536-53-5]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₀H₁₂N₆O₇
Molecular weight [g/mol] 328,3
Absorption max [nm] 390
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 4100
  • 1. Ahtesham A. K., Sawa T.Akaike T., Amino Acids, 41, 123 - 130 (2011), "Protein Cysteine S-guanylation and Electrophilic Signal Transduction by Endogenous Nitro-nucleotides"
  • 2. Saito Y., Taguchi H., Fujii S., Sawa T., Kida E., Kabuto C., Akaike T.Arimoto H., Chem. Commun., 0, 5984 - 5986 (2008), "8-Nitroguanosines as Chemical Probes of the Protein S-guanylation"
  • 3. Kaneko K., Akuta T., Sawa T., Kim H.-W., Fujii S., Okamoto T., Nakayama H., Ohigashi H., Murakami A.Akaike T., Cancer Lett., 262, 239 - 247 (2008), "Mutagenicity of 8-nitroguanosine, a Product of Nitrative Nucleoside Modification by Reactive Nitrogen Oxides, in Mammalian Cells"
  • 4. Yoshitake J., Kato K., Yoshioka D., Sueishi Y., Sawa T., Akaike T.Yoshimura T., Nitric Oxide, 18, 223 - 228 (2008), "Suppression of NO Production and 8-nitroguanosine Formation by Phenol-containing Endocrine-disrupting Chemicals in LPS-stimulated Macrophages: Involvement of Estrogen Receptor-dependent or Independent Pathways"
  • 5. Akuta T., Zaki M. H., Yoshitake J., Okamoto T.Akaike T., Nitric Oxide, 14, 101 - 108 (2006), "Nitrative Stress through Formation of 8-Nitroguanosine: Insights into Microbial Pathogenesis"
  • 6. Horiike S., Kawanishi S., Kaito M., Ma N., Tanaka H., Fujita N., Iwasa M., Kobayashi Y., Hiraku Y., Oikawa S., Murata M., Wang J., Semba R., Watanabe S.Adachi Y., J. Hepatol., 43, 403 - 410 (2005), "Accumulation of 8-Nitroguanine in the Liver of Patients with Chronic Hepatitis C"
  • 7. Yoshitake J., Akaike T., Akuta T., Tamura F., Ogura T., Esumi H.Maeda H., J. Virology, 78, 8709 - 8719 (2004), "Nitric Oxide as an Endogenous Mutagen for Sendai Virus without Antiviral Activity"
  • 8. Masuda M., Nishino H.Ohshima H., Chemico-Biological Interactions, 139, 187 - 197 (2002), "Formation of 8-Nitroguanosine in Cellular RNA as a Biomarker of Exposure to Reactive Nitrogen Species"
  • 9. Masuda M., Suzuki T., Friesen M. D., Ravanat J.-L., Cadet J., Pignatelli B., Nishino H.Oshima H., J. Biol. Chem., 276, 40486 - 40496 (2001), "Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils"
  • 10. Sawa T., Akaike T., Fang J.Maeda H., Intl. Soc. Prev. Oncol. poster contribution # 442, 0, 0 - 0 (2000), "Enzymatic Activation of Damaged Nucleoside 8- Nitroguanosine to Generate Free Radical by Cytochrome P450 Reductase"