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8- Bromo- N1- cyclic inosine diphosphate ribose ( 8-Br-N1-cIDPR ), sodium salt

Analogue of cADPR with higher permeability and stability
Cat. No.: B 071
CAS No.: [638195-70-7]
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Product Name Price (net) Qty
Cat. No.: B 071-005
Unit: 0.5 µmol / ~311 µg
For other salt forms or higher purity please inquire. 

Hydrolysis-resistant agonist of the second messenger cyclic ADP ribose (Cat. No. C 005) with increased membrane permeability. Detailed technical information and references available. References: Kirchberger et al.,  Brit. J. Pharmacol., 149, 337 - 344 (2006); Kirchberger et al., Biochem. J., 422, 139 - 149 (2009).
Cat. No. B 071
CAS number [638195-70-7]
Purity > 97 % HPLC; contains no buffer salts
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₅H₁₉BrN₄O₁₄P₂ (free acid)
Molecular weight [g/mol] 621,2 (free acid)
Absorption max [nm] 255
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 11145
UV pH value 4.9
  • 1. Kirchberger T., Moreau C., Wagner G. K., Fliegert R., Siebrands C. C., Nebel M., Schmid F., Harneit A., Odoardi F., Flügel A., Potter B. V. L.Guse A. H., Biochem. J., 422, 139 - 149 (2009), "8-Bromo-Cyclic Inosine Diphosphoribose: Towards a Selective Cyclic ADP-Ribose Agonist"
  • 2. Kirchberger T., Wagner G., Xu J., Cordiglieri C., Wang P., Gasser A., Fliegert R., Bruhn S., Flügel A., Lund F. E., Zhang L.-H., Potter B. V. L.Guse A. H., Br. J. Pharmacol., 149, 337 - 344 (2006), "Cellular Effects and Metabolic Stability of N1-Cyclic Inosine Diphosphoribose and its Derivatives"
  • 3. Guse A. H., FEBS J., 272, 4590 - 4597 (2005), "Second Messenger Function and the Structure-activity Relationship of Cyclic Adenosine Diphosphoribose (cADPR)"