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8-Br-cADPR

8- Bromo- cyclic adenosine diphosphate ribose ( 8-Br-cADPR ), sodium salt
Antagonist of the second messenger cyclic ADP ribose
Cat. No.: B 065
    
CAS No.: [151898-26-9]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: B 065-005
Unit: 0.5 µmol / ~310 µg
$77.00

For other salt forms or higher purity please inquire. Antagonist of the second messenger cyclic ADP ribose (Cat. No. C 005) with increased membrane permeability. Detailed technical information and references available. References: Walseth & Lee, Biochim. Biophys. Acta, 1178, 235 - 242 (1993); Guse, FEBS J., 272, 4590 - 4597 (2005); Guse et al., J. Biol. Chem., 280, 15952 - 15959 (2005).

Cat. No. B 065
CAS number [151898-26-9]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -70°C / -94°F
Molecular formula C₁₅H₂₀BrN₅O₁₃P₂ (free acid)
Molecular weight [g/mol] 620,2 (free acid)
Absorption max [nm] 264
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15730
  • 1. Rah S.-Y., Mushtaq M., Nam T.-S., Kim S. H.Kim U.-H., J. Biol. Chem., 285, 21877 - 21887 (2010), "Generation of Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by CD38 for Ca2+ Signaling in Interleukin-8-treated Lymphokine-activated Killer Cells"
  • 2. Mayo L., Jacob-Hirsch J., Amariglio N., Rechavi G., Moutin M.-J., Lund F. E.Stein R., J. Immunol., 181, 92 - 103 (2008), "Dual Role of CD38 in Microglial Activation and Activation-Induced Cell-Death"
  • 3. Partida-Sanchez S., Gasser A., Fliegert R., Siebrands C. C., Dammermann W., Shi G., Mousseau B. J., Sumoza-Toledo A., Bhagat H., Walseth T. F., Guse A. H.Lund F. E., J. Immunol., 179, 7827 - 7839 (2007), "Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction"
  • 4. Kirchberger T., Wagner G., Xu J., Cordiglieri C., Wang P., Gasser A., Fliegert R., Bruhn S., Flügel A., Lund F. E., Zhang L.-H., Potter B. V. L.Guse A. H., Br. J. Pharmacol., 149, 337 - 344 (2006), "Cellular Effects and Metabolic Stability of N1-Cyclic Inosine Diphosphoribose and its Derivatives"
  • 5. Guse A. H., Gu X., Zhang L., Weber K., Krämer E., Yang Z., Jin H., Li Q., Carrier L.Zhang l., J. Biol. Chem., 280, 15952 - 15959 (2005), "A Minimal Structural Analogue of Cyclic ADP-ribose - Synthesis and Calcium Release Activity in Mammalian Cells"
  • 6. Guse A. H., FEBS J., 272, 4590 - 4597 (2005), "Second Messenger Function and the Structure-activity Relationship of Cyclic Adenosine Diphosphoribose (cADPR)"
  • 7. Hashii M., Shuto S., Fukuoka M., Kudoh T., Matsuda A.Higashida H., J. Neurochem., 94, 316 - 323 (2005), "Amplification of Depolarization-induced and Ryanodine-sensitive Cytosolic Ca2+ Elevation by Synthetic Carbocyclic Analogs of Cyclic ADP-ribose and Their Antagonistic Effects in NG108-15 Neuronal Cells"
  • 8. Kumar N. V., Eblen S. T.Weber M. J., Methods, 32, 389 - 397 (2004), "Identifying Specific Kinase Substrates through Engineered Kinases and ATP Analogs"
  • 9. Partida-Sánchez S., Iribarren P., Moreno-García M. E., Gao J.-L., Murphy P. M., Oppenheimer N., Wang J. M.Lund F. E., J. Immunol., 172, 1896 - 1906 (2004), "Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose"
  • 10. Partida-Sanchez S., Cockayne D. A., Monard S., Jacobson E. L., Oppenheimer N., Garvy B., Kusser K., Goodrich S., Howard M., Harmsen A., Randall T. D.Lund F. E., Nat. Med., 7, 1209 - 1216 (2001), "Cyclic ADP-Ribose Production by CD38 Regulates Intracellular Calcium Release, Extracellular Calcium Influx and Chemotaxis in Neutrophils and is Required for Bacterial Clearance In Vivo"
  • 11. Walseth T. F.Lee H. C., Biochim Biophys Acta, 1178, 235 - 242 (1993), "Synthesis and Characterization of Antagonists of Cyclic-ADP-ribose-induced Ca2+ release"
  • 12. Rah S.-Y., Kwak J.-Y.Kim U.-H., Scientific Reports, 0, 0 - 0 (0), "ADP-Ribose/TRM2-mediated Ca2+ Signaling is Essential for Cytolytic Degranulation and Antitumor Activity of Natural Killer Cells"