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6-(3-MeBn)-ADP

N6- (3- Methylbenzyl)adenosine- 5'- O- diphosphate ( 6-(3-MeBn)-ADP ), sodium salt

Cat. No.: M 024
    
CAS No.: [681175-78-0]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: M 024-05
Unit: 5 µmol / ~2.7 mg
$303.00

Precursor for the preparation of the corresponding radio-labelled triphosphate to be used in the chemical genetics approach (compare: Habelhah et al., J. Biol. Chem., 276, 18090 - 18095 (2001)). The corresponding cold triphosphate is offered as well (Cat. No. M 025). Detailed technical information available. References: Shah et al., Proc. Natl. Acad. Sci. USA, 94, 3565 - 3570 (1997); Gillespie et al., J. Biol. Chem., 274, 31373 - 31381 (1999).

 

 Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. M 024
CAS number [681175-78-0]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₈H₂₃N₅O₁₀P₂ (free acid)
Molecular weight [g/mol] 531,4 (free acid)
Absorption max [nm] 269
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 20500
  • 1. Habelhah H., Shah K., Huang L., Burlingame A. L., Shokat K. M.Ronai Z., J. Biol. Chem., 276, 18090 - 18095 (2001), "Identification of New JNK Substrate Using ATP Pocket Mutant JNK and a Corresponding ATP Analogue"
  • 2. Gillespie P. G., Gillespie S. K. H., Mercer J. A., Shah K.Shokat K. M., J. Biol. Chem., 274, 31373 - 31381 (1999), "Engineering of the Myosin-Iß Nucleotide-binding Pocket to Create Selective Sensitivity to N6-modified ADP Analogs"
  • 3. Shah K., Liu Y., Deirmengian C.Shokat K. M., Proc. Natl. Acad. Sci. USA, 94, 3565 - 3570 (1997), "Engineering Unnatural Nucleotide Specificity for Rous Sarcoma Virus Tyrosine Kinase to Uniquely Label its Direct Substrates"