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Alternative structural projections:

5,6-DM-cBIMP

5, 6- Dimethylbenzimidazole riboside- 3', 5'- monophosphate ( 5,6-DM-cBIMP ), sodium salt
Membrane-permeant activator of PDE II
Cat. No.: D 001
    
CAS No.: [142754-31-2]
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Cat. No.: D 001-05
Unit: 5 µmol / ~1.8 mg
$212.00
Membrane-permeant activator of phosphodiesterase type II with only very poor activation potential for protein kinase G. Detailed technical information and references available. Reference: Genieser et al., Carbohydr. Res., 234, 217 - 235 (1992); Jäger et al., Br. J. Pharmacol., 161, 1645 - 1660 (2010).
Cat. No. D 001
CAS number [142754-31-2]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₄H₁₆N₂O₆P · Na
Molecular weight [g/mol] 362,3
Modifications 1-cAMP, 2-cAMP, 3-cAMP, 6-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.48
Absorption max [nm] 279
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 7500
Solvent for UV data MeOH
  • 1. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 2. Matthiesen K.Nielsen J., Biochem. J., 423, 401 - 409 (2009), "Binding of Cyclic Nucleotides to Phosphodiesterase 10A and 11A GAF Domains Does Not Stimulate Catalytic Activity"
  • 3. Jin X. H., Siragy H. M.Carey R. M., Hypertension, 38, 309 - 316 (2001), "Renal Interstitial cGMP Mediates Natriuresis by Direct Tubule Mechanism"
  • 4. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"
  • 5. Genieser H.-G., Winkler E., Butt E., Zorn M., Schulz S., Iwitzki F., Störmann R., Jastorff B., Doeskeland S. O., Oegreid D., Ruchaud S.Lanotte M., Carbohydr. Res., 234, 217 - 235 (1992), "Derivates of 1-ß-D-Ribofuranosylbenzimidazole 3', 5'-phosphate that Mimic the Actions of Adenosine 3', 5',- phosphate (cAMP) and Guanosine 3', 5'- phosphate (cGMP)"