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Alternative structural projections:

2'-O-Me-cAMP

2'- O- Methyladenosine- 3', 5'- cyclic monophosphate ( 2'-O-Me-cAMP ), sodium salt
Polar Epac agonist
Cat. No.: M 050
    
CAS No.: [40269-29-2]
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Product Name Price (net) Qty
Cat. No.: M 050-05
Unit: 5 µmol / ~1.8 mg
$109.00
For other salt forms please inquire. Relatively polar analogue of cyclic AMP which does not activate protein kinase A. Suitable for Epac activation by patch clamp application techniques and for receptor mapping studies. The structurally related cGMP-based analogue 2'-O-Me-cGMP is offered as well (Cat. No. M 036). Detailed technical information available. Reference: Kang et. al., J. Physiol., 573, 595 - 609 (2006).
Cat. No. M 050
CAS number [40269-29-2]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₁H₁₃N₅O₆P · Na
Molecular weight [g/mol] 365,2
Modifications 2'-cAMP
Target Epac Activator
Lipophilicity 1.34
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Leech C. A., Dzhura I., Chepurny O. G., Schwede F., Genieser H.-G.Holz G. G., Islets, 2, 72 - 81 (2010), "Facilitation of beta-cell KATP Channel Sulfonylurea Sensivity by a cAMP Analog Selective for the cAMP-regulated Guanine Nucleotide Exchange Factor Epac"
  • 2. Holz G. G., Chepurny O. G.Schwede F., Cell. Signal., 20, 10 - 20 (2008), "Epac-selective cAMP Analogs: New Tools with which to Evaluate the Signal Transduction Properties of cAMP-regulated Guanine Nucleotide Exchange Factors"
  • 3. Kang G., Leech C. A., Chepurny O. G., Coetzee W. A.Holz G. G., J. Physiol., 587, 1307 - 1319 (2008), "Role of the cAMP Sensor Epac as a Determinant of K-ATP Channel ATP-Sensitivity in Human Pancreatic β-Cells and RAT INS-1 Cells"
  • 4. Kang G., Chepurny O. G., Malester B., Rindler M. J., Rehmann H., Bos J. L., Schwede F., Coetzee W. A.Holz G. G., J. Physiol.-London, 573, 595 - 609 (2006), "cAMP Sensor Epac as a Determinant of ATP-sensitive Potassium Channel Activity in Human Pancreatic Beta Cells and Rat INS-1 Cells"
  • 5. Kopperud R. K., Krakstad C., Selheim F.Doeskeland S. O., FEBS Lett., 546, 121 - 126 (2003), "cAMP Effector Mechanisms. Novel Twists for an 'Old' Signaling System"