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Alternative structural projections:

2-Cl-8-HA-cAMP

2- Chloro- 8- n- hexylaminoadenosine- 3', 5'- cyclic monophosphate ( 2-Cl-8-HA-cAMP ), sodium salt
Cat. No.: C 071
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: C 071-05
Unit: 5 µmol / ~2.4 mg
$245.00
For other salt forms please inquire.
Cyclic AMP analogue with high selectivity for site B I of PKA and good membrane permeability. Combined with AI-selective analogues synergistic activation of PKA type I is achieved. Detailed technical information available. Reference: Huseby et al., Cell Death Dis., 2, e237 (2011).
Cat. No. C 071
CAS number [pending]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₃ClN₆O₆P · Na
Molecular weight [g/mol] 484,8
Modifications 2-cAMP
Lipophilicity 3.08
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Gausdal G., Wergeland A., Skavland J., Nguyen E., Pendino F., Rouhee N., McCormack E., Herfindal L., Kleppe R., Havemann U., Schwede F., Bruseud O., Gjertsen B. T., Lanotte M., Segal-Bendirdjian E.Doskeland S. O., Cell Death Dis., 4, 0 - 0 (2013), "Cyclic AMP Can Promote APL Progression and Protect Myeloid Leukemia Cells Against Anthracycline-Induced Apoptosis"
  • 2. Huseby S., Gausdal G., Keen T. J., Kjærland E., Krakstad C., Myhren L., Brønstad K., Kunick C., Schwede F., Genieser H.-G., Kleppe R.Doeskeland S. O., Cell Death Dis., e237, 2, 0 - 0 (2011), "Cyclic AMP Induces IPC Leukemia Cell Apoptosis via CRE-and CDK-dependent Bim Transcription"