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Potent peptide-based inhibitor of protein kinase G type I α and I β, which is not membrane-permeant. Can be used for studies with DT-2, (D)-DT-2 and DT-3 as a control. Detailed technical information available. Reference: Dostmann et al., Proc. Natl. Acad. Sci. USA, 97, 14772 - 14777 (2000).
Cat. No.
W 001
CAS number
[pending]
Purity
> 95% HPLC
Salt form
TFA
Storage temperature
-20°C / -4°F
Molecular formula
C₄₈H₉₃N₁₉O₈
Molecular weight [g/mol]
1064.4 for free peptide
1. Nickl C. K., Raidas S. K., Zhao H., Sausbier M., Ruth P., Tegge W., Brayden J. E.Dostmann W. R. G., Biochim. Biophys. Acta, 1804, 524 - 532 (2010), "(D)-Amino Acid Analogues of DT-2 as Highly Selective and Superior Inhibitors of cGMP-dependent Protein Kinase I alpha"
3. Pinkse M. W. H., Rijkers D. T. S., Dostmann W. R.Heck A. J. R., J. Bio. Chem., 284, 16354 - 16368 (2009), "Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry"
4. Dostmann W. R. G., Taylor M. S., Nickl C. K., Brayden J. E., Frank R.Tegge W., Proc. Natl. Acad. Sci. U.S.A., 97, 14772 - 14777 (2000), "Highly Specific, Membrane-permeant Peptide Blockers of cGMP-dependent Protein Kinase I Alpha Inhibit NO-induced Cerebral Dilation"