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PKG inhibitor peptide W45
Peptide-based, membrane-impermeant inhibitor of protein kinase G I α and I β
Cat. No.: W 001
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: W 001-005
Unit: 0.5 mg / ~0.47 µmol
Potent peptide-based inhibitor of protein kinase G type I α and I β, which is not membrane-permeant. Can be used for studies with DT-2, (D)-DT-2 and DT-3 as a control. Detailed technical information available. Reference: Dostmann et al., Proc. Natl. Acad. Sci. USA, 97, 14772 - 14777 (2000).
Cat. No. W 001
CAS number [pending]
Purity > 95% HPLC
Salt form TFA
Storage temperature -20°C / -4°F
Molecular formula C₄₈H₉₃N₁₉O₈
Molecular weight [g/mol] 1064.4 for free peptide
  • 1. Nickl C. K., Raidas S. K., Zhao H., Sausbier M., Ruth P., Tegge W., Brayden J. E.Dostmann W. R. G., Biochim. Biophys. Acta, 1804, 524 - 532 (2010), "(D)-Amino Acid Analogues of DT-2 as Highly Selective and Superior Inhibitors of cGMP-dependent Protein Kinase I alpha"
  • 2. Koika V., Zhou Z., Vasileidis I., Roussos C., Finetti F., Monti M., Morbidelli L.Papapetropoulos A., Vasc. Pharmacol., 53, 215 - 222 (2010), "PKG-I Inhibition Attenuates Vascular Endothelial Growth Factor-stimulated Angiogenesis"
  • 3. Pinkse M. W. H., Rijkers D. T. S., Dostmann W. R.Heck A. J. R., J. Bio. Chem., 284, 16354 - 16368 (2009), "Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry"
  • 4. Dostmann W. R. G., Taylor M. S., Nickl C. K., Brayden J. E., Frank R.Tegge W., Proc. Natl. Acad. Sci. U.S.A., 97, 14772 - 14777 (2000), "Highly Specific, Membrane-permeant Peptide Blockers of cGMP-dependent Protein Kinase I Alpha Inhibit NO-induced Cerebral Dilation"