For other salt forms please inquire. Fluorescent analogue of GTP with λexc 408 nm and λem 552 nm, which can substitute for GTP in the interaction with various enzymes and proteins. It is sensitive to indicators of local environment such as polarity and viscosity, and frequently exhibits a spectral shift and fluorescence enhancement upon binding to a protein. Inhibitor of soluble guanylyl cyclase (sGC). Detailed technical information available. References: Hiratsuka, T., J. Biol. Chem., 260, 4784 - 4790 (1985); Suryanarayana et al., J. Pharmacol. Exp. Ther., 330, 687 - 695 (2009).
Vial containing 500 µl of 10 mM aqueous solution of pH 8
| Cat. No. | T 026 |
| CAS number | [612837-26-0] |
| Purity | > 95% HPLC |
| Salt form | Sodium |
| Appearance | 10 mM aqueous solution of pH 8 |
| Storage temperature | -70°C / -94°F |
| Light-sensitive | True |
| Molecular formula | C₁₆H₁₇N₈O₂₀P₃ (free acid) |
| Molecular weight [g/mol] | 734.3 (free acid) |
| Excitation max [nm] | 408 |
| Emission max [nm] | 552 |
| Absorption max [nm] | 408 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 26500 |
| UV pH value | 8 |
- 1. Suryanarayana S., G�ttle M., H�bner A., Gille A., Mou T.-C., Sprang S. R., Richter M.Seifert R., J. Pharmacol. Exp. Ther., 330, 687 - 695 (2009), "Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2',3'-O-(2,4,6-Trinitrophenyl)-substituted Nucleoside 5'-triphosphates"
- 2. Hiratsuka T., Eur. J. Biochem., 270, 3479 - 3485 (2003), "Fluorescent and Colored Trinitrophenylated Analogs of ATP and GTP"
- 3. Virginio C., Robertson G., Surprenant A.North R. A., Mol. Pharmacol., 53, 969 - 973 (1998), "Trinitrophenyl-substituted Nucleotides are Potent Antagonists Selective for P2X1, P2X3, and heteromeric P2X2/3 Receptors"
- 4. Hiratsuka T., J. Biol. Chem., 260, 4784 - 4790 (1985), "A Chromophoric and Fluorescent Analog of GTP, 2',3'-O-(2,4,6-Trinitrocyclohexadienylidene)-GTP, as a Spectroscopic Probe for the GTP Inhibitory Site of Liver Glutamate Dehydrogenase"
