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Interesting Papers for Cyclic Nucleotide Reseach

Epac:

These papers focus on discrimination between Epac- and PKA-mediated effects:

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Rehmann, H.; Schwede, F.; Døskeland, S.O.; Wittinghofer, A.; Bos, J.L., J. Biol. Chem., 278, 38548 - 38556 (2003): "Ligand-mediated Activation of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac"

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Christensen, A.E.; Selheim, F.; de Rooij, J.; Dremier, S.; Schwede, F.; Dao, K.K.; Martinez, A., Maenhaut, C.; Bos, J.L; Genieser, H.-G..; Døskeland, S.O., J. Biol. Chem., 278, 35394 - 35402 (2003): "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"

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Kang, G.; Joseph, J.W.; Chepurny, O.G.; Monaco, M.; Wheeler, M.B.; Bos, J.L.; Schwede, F.; Genieser, H.-G.; Holz, G.G., J. Biol. Chem., 278, 8279 - 8285 (2003): "Epac-selective cAMP Analog 8-pCPT-2'-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic beta-Cells"

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EnserinkJ.M.; Christensen, A.E.; de Rooij, J.; van Triest, M.; Schwede, F.; Genieser, H.-G.; Døskeland,S.O.; Bos, J.L., Nature Cell Biol., 4, 901 - 906, 2002: "A novel Epac-specific cAMP Analog Demonstrates Independent Regulation of Rap1 and ERK by cAMP"

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Christensen, A.E.; de Rooij, J.; Kopperud, R.; Nilsen, O.K.; Dao, K.K.; Schwede, F.; Bos, J.L.; Genieser, H.-G.; Døskeland, S.O., Abstracts of the 13th Protein Kinase Symposium, Oslo/Norway, 2002: "Comparison of the cAMP Binding Sites of EPAC-1 and cAMP-Kinase"

 

Cyclic Nucleotide-gated Ion channels:

The following papers give interesting information about the properties of phosphorothioate-modified cyclic nucleotides with respect to cAMP/cGMP-gated ion channels:

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Wei, J.Y.; Cohen, E.D.; Yan, Y.Y.; Genieser, H.-G.; Barnstable, C.J., Biochemistry, 35, 16815 - 16823 (1996): "Identification of Competitive Antagonists of the Rod Photoreceptor cGMP-gated Cation Channel- β-Phenyl- 1, N2- Etheno-substituted cGMP Analogues as probes of the cGMP-binding site"

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Kramer, R.H; Tibbs, G.R., J. Neuroscience 16, 1285 - 1293 (1996): "Antagonists of Cyclic Nucleotide-gated Channels and Molecular Mapping of their Site of Action"