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Alternative structural projections:

Sp-8-AET-cGMPS-Agarose

8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel ( Sp-8-AET-cGMPS-Agarose )
Immobilized PDE-resistant PKG agonist
Cat. No.: A 010
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 010-06
Unit: 0.6 ml
$238.00
Cat. No.: A 010-25
Unit: 2.5 ml
$744.00
Cat. No.: A 010-60
Unit: 6 ml
$1,449.00

The protein kinase G activator Sp-cGMPS (Cat. No. G 017) immobilized on agarose by an aminoethylthio spacer attached to position 8 of the ligand. Free Sp-cGMPS is only very slowly metabolized and thus represents an extraordinary stable ligand. In addition, its reduced binding affinity towards protein kinase G compared to cGMP should result in potentially milder desorption conditions in affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Detailed technical information available.
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.

 

Appearance: Suspension in 30 mM Na2HPO4 buffer (pH 7).

Cat. No. A 010
CAS number [pending]
Appearance Suspension in 30 mM Na₂HPO₄ buffer (pH 7)
Storage temperature 4°C / 39°F
Modifications 8-cGMP
  • 1. Wolfe L., Corbin J. D.Francis S. H., J. Biol. Chem., 264, 7734 - 7741 (1989), "Characterization of a Novel Isozyme of cGMP-dependent Protein Kinase From Bovine Aorta"