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Alternative structural projections:

Sp-6-Phe-cAMPS

N6- Phenyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-Phe-cAMPS ), sodium salt

PDE-resistant form of N6-Phenyl-cAMP
Cat. No.: P 018
    
CAS No.: [169335-92-6]
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Product Name Price (net) Qty
Cat. No.: P 018-05
Unit: 5 µmol / ~2.2 mg
$226.00
Potent site-selective, highly membrane-permeant and PDE-resistant activator of protein kinase A. Sp-6-Phe-cAMPS does not activate Epac and thus can be used as an Epac-negative control. For more details on site selectivity please inquire. Detailed technical information available. References: Gjertsen et al., J. Biol. Chem., 270, 20599 - 20607 (1995); Ouyang et al., Proc. Natl. Acad. Sci. USA, 105, 11993 - 11997 (2008).
Cat. No. P 018
CAS number [169335-92-6]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₁₅N₅O₅PS · Na
Molecular weight [g/mol] 443.4
Target PKA (cAK) Activator
Lipophilicity 2.70
Absorption max [nm] 288
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 20800
  • 1. Ouyang M., Zhang L., Zhu J. J., Schwede F.Thomas S. A., PNAS, 105, 11993 - 11997 (2008), "Epac Signaling is Required for Hippocampus-dependent Memory Retrieval"
  • 2. Gjertsen B. T., Mellgren G., Otten A., Maronde E., Genieser H.-G., Jastorff B., Vintermyr O. K., McKnight G. S.Doeskeland S. O., J. Biol. Chem., 270, 20599 - 20607 (1995), "Novel (Rp)-cAMPS Analogs as Tools for Inhibition of cAMP-Kinase in Cell Culture"