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6- Chloropurine riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-Cl-cPuMPS ), sodium salt
Cat. No.: C 083
CAS No.: [129693-12-5]
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Cat. No.: C 083-05
Unit: 5 µmol
PDE-resistant activator of protein kinase A (cyclic AMP agonist) with reactive functional group allowing further chemical modifications. Significantly more lipophilic and membrane-permeant compared to Sp-cAMPS (Cat. No. A003). Detailed technical information and updated reference list available. References: Ruchaud et al., Cell. Pharmacol., 2, 127 - 140 (1995); Schaap et al., J. Biol. Chem., 268, 6323 - 6331 (1993); Dostmann et al., J. Biol. Chem., 265, 10484 - 10491 (1990).
Cat. No. C 083
CAS number [129693-12-5]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₉ClN₄O₅PS · Na
Molecular weight [g/mol] 386.7
Target PKA (cAK) Activator
Lipophilicity 1.65
Absorption max [nm] 263
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 8900
  • 1. Ruchaud S., Zorn M., Davilar-Villar E., Genieser H.-G., Hoffmann C., Gjertsen B. T., Doeskeland S. O., Jastorff B.Lanotte M., Cell. Pharmacol., 2, 127 - 140 (1995), "Evidence for Several Pathways of Biological Response to Hydrolysable cAMP-Analogues Using a Model System of Apoptosis in IPC-81 Leukaemia Cells"
  • 2. Schaap P., Van Ments-Cohen M., Soede R. D. M., Brandt R., Firtel R. A., Dostmann W., Genieser H.-G., Jastorff B.Van Haastert P. J. M., J. Biol. Chem., 268, 6323 - 6331 (1993), "Cell-permeable Non-hydrolyzable cAMP Derivatives as Tools for Analysis of Signaling Pathways Controlling Gene Regulation in Dictyostelium"
  • 3. Dostmann W. R. G., Taylor S. S., Genieser H.-G., Jastorff B., Doeskeland S. O.Oegreid D., J. Biol. Chem., 265, 10484 - 10491 (1990), "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinase I and II with Analogs of Adenosine- 3', 5'- Cyclic Phosphorothioates"