(Cat. No. A 003) immobilized on agarose by an aminohexyl spacer attached to position 6 of the ligand. Free Sp-cAMPS is only very slowly metabolized by mammalian phosphodiesterases and thus represents an extraordinary stable ligand. In addition, its reduced binding affinity towards protein kinase A compared to cAMP results in milder desorption conditions in affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. This type of gel is offered with a shorter spacer (Sp-6-AE-cAMPS-Agarose
, Cat. No. A 109) as well. Detailed technical information available.Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.